Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

413
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
413
Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

2.9K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
2.9K
Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

3.2K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
3.2K
Recrystallization: Solid–Solution Equilibria01:10

Recrystallization: Solid–Solution Equilibria

1.2K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
1.2K
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

208
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
208
Colloidal precipitates01:09

Colloidal precipitates

809
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
809

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Call For Papers: Molecular Understanding and Formulation Design for Peptide Delivery.

Molecular pharmaceutics·2026
Same author

Force Distribution and Contact Mechanics in Mini-Tablet Compaction: A Discrete Element Method Study.

Pharmaceutical research·2026
Same author

Analyzing Spatial Variations in Molecular Mobility in Hydrated Amorphous Drug-Polymer Blends Using Fourier Transform Fluorescence Recovery After Photobleaching and Image Segmentation.

The journal of physical chemistry. B·2026
Same author

The expanding role of formulations to enable oral delivery of poorly water-soluble drugs.

Nature reviews. Drug discovery·2026
Same author

Addressing the Release and Permeation Challenges of High-<i>T</i><sub><i>g</i></sub> Drugs in Amorphous Solid Dispersions.

Molecular pharmaceutics·2026
Same author

Investigating the Relationship between In Vitro and In Vivo Performance: The Role of Drug Loading, Release Rate, and Surface Area.

Molecular pharmaceutics·2026

Related Experiment Video

Updated: Sep 28, 2025

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
09:15

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering

Published on: August 14, 2018

10.6K

Formulation and Processing Strategies which Underpin Susceptibility to Matrix Crystallization in Amorphous Solid

Dana E Moseson1, Tze Ning Hiew1, Yongchao Su2

  • 1Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.

Journal of Pharmaceutical Sciences
|April 3, 2022
PubMed
Summary

Matrix crystallization in amorphous solid dispersions (ASDs) is influenced by drug loading, mechanical activation, and surfactants. High risk factors increase crystallization, while rapid drug and polymer release enhances stability.

Keywords:
Amorphous solid dispersionCongruent releaseDissolutionMatrix crystallizationSupersaturation

More Related Videos

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
07:42

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

2.0K
Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

5.6K

Related Experiment Videos

Last Updated: Sep 28, 2025

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
09:15

Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering

Published on: August 14, 2018

10.6K
On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature
07:42

On-Chip Crystallization and Large-Scale Serial Diffraction at Room Temperature

Published on: March 11, 2022

2.0K
Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

5.6K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Physical Chemistry

Background:

  • Amorphous solid dispersions (ASDs) enhance drug solubility and bioavailability.
  • Matrix crystallization is a key instability pathway in ASDs, reducing dissolution.
  • Understanding crystallization mechanisms is crucial for stable ASD formulation.

Purpose of the Study:

  • To investigate the mechanism of matrix crystallization in amorphous solid dispersions (ASDs).
  • To identify factors influencing the risk of matrix crystallization in ASDs.
  • To provide insights for formulation and process design of stable ASDs.

Main Methods:

  • Preparation of bicalutamide/copovidone ASDs via solvent evaporation and hot melt extrusion.
  • Mechanical activation of ASDs using mortar and pestle or cryomilling.
  • Characterization using SEM-EDX, confocal fluorescence microscopy, and dissolution monitoring under non-sink conditions.

Main Results:

  • High drug loading (DL), mechanical activation, and surfactant presence increased matrix crystallization risk.
  • Ternary systems with surfactants showed increased susceptibility to crystallization.
  • Rapid and congruent drug and polymer release correlated with resistance to matrix crystallization.

Conclusions:

  • Formulation and processing parameters significantly impact ASD stability against matrix crystallization.
  • High DL, mechanical stress, and surfactants are risk factors for ASD instability.
  • Optimizing drug and polymer release profiles is critical for preventing matrix crystallization and ensuring ASD performance.