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ALB-dNLR Score Predicts Mortality in Coronary Artery Disease Patients After Percutaneous Coronary Intervention

Wen-Juan Xiu1, Hai-Tao Yang1, Ying-Ying Zheng1,2

  • 1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Frontiers in Cardiovascular Medicine
|April 4, 2022
PubMed

Insights

The albumin/derived neutrophil and lymphocyte ratio (ALB-dNLR) score predicts mortality in patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI). Higher ALB-dNLR scores are associated with increased risks of all-cause and cardiac mortality post-PCI.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation Markers

Background:

  • The prognostic value of the albumin/derived neutrophil and lymphocyte ratio (ALB-dNLR) in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) remains unclear.
  • Inflammatory markers are increasingly recognized for their role in cardiovascular disease outcomes.

Purpose of the Study:

  • To investigate the association between the ALB-dNLR score and patient outcomes following PCI.
  • To determine if ALB-dNLR can serve as a predictive biomarker for mortality in CAD patients post-PCI.

Main Methods:

  • A cohort of 6,050 patients undergoing PCI was analyzed.
  • Patients were stratified into three groups based on ALB-dNLR scores.
  • Cox proportional hazard models were used to assess the predictive value of ALB-dNLR for all-cause mortality (ACM) and cardiac mortality (CM).

Main Results:

  • Significant differences in ACM and CM rates were observed across ALB-dNLR score groups.
  • The ALB-dNLR score independently predicted both ACM and CM in multivariate analysis.
  • These predictive associations were also observed specifically in male patients.

Conclusions:

  • The ALB-dNLR score is a reliable predictor of mortality in patients with CAD after PCI.
  • Elevated ALB-dNLR scores indicate a higher risk of adverse outcomes, including death, post-PCI.
Abstract

Keywords:
albumin and the derived neutrophil to lymphocyte ratio score (ALB-dNLR score)all-cause mortalitycardiac mortalitycoronary artery diseasemajor adverse cardiovascular and cerebrovascular eventsmajor adverse cardiovascular eventsmortalitypercutaneous coronary intervention

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