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Related Concept Videos

Auditory Pathway01:15

Auditory Pathway

5.9K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
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The Cochlea01:13

The Cochlea

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The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
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Related Experiment Video

Updated: Sep 28, 2025

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
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Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

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Integrative Functional Transcriptomic Analyses Implicate Shared Molecular Circuits in Sensorineural Hearing Loss.

Peng Chen1,2, Jun-Jun Hao1, Meng-Wen Li1

  • 1State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.

Frontiers in Cellular Neuroscience
|April 4, 2022
PubMed
Summary
This summary is machine-generated.

Sensorineural hearing loss (SNHL) shares common molecular pathways across aging, noise, and drug-induced causes. Identifying these shared mechanisms, like apoptosis and inflammation, offers new therapeutic targets for hearing loss.

Keywords:
agingco-expression networkcommon molecular mechanismsnoise exposureototoxic drugssensorineural hearing loss

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Area of Science:

  • Oto-neuroscience
  • Genomics
  • Molecular Biology

Background:

  • Sensorineural hearing loss (SNHL) is the most common form of hearing impairment, resulting from damage to the inner ear or auditory nerve.
  • Aging, noise exposure, and ototoxic drugs are primary SNHL causes, exhibiting similar cochlear degeneration patterns.
  • The underlying common molecular mechanisms for these similarities require systematic investigation.

Purpose of the Study:

  • To investigate shared molecular mechanisms across different etiologies of SNHL.
  • To identify common gene co-expression networks and regulatory pathways in SNHL mouse models.
  • To uncover potential therapeutic targets for SNHL.

Main Methods:

  • Generated three SNHL mouse models: aging, noise-induced, and cisplatin-induced.
  • Constructed cochlear transcriptome gene co-expression networks.
  • Performed bioinformatics analyses to identify hub regulators and biological functions.

Main Results:

  • Significant correlations were found between the three SNHL models in gene co-expression modules.
  • These modules are involved in critical biological functions, including apoptosis, immune response, inflammation, and ion transport.
  • Identified IL1B and CCL2 as potential hub regulators, confirmed to promote apoptosis and reactive oxygen species (ROS) production in vitro.

Conclusions:

  • Disentangled shared molecular circuits underlying diverse SNHL types.
  • Highlights IL1B and CCL2 as key players in SNHL pathogenesis.
  • Provides potential targets for developing broad-acting therapeutic agents for SNHL.