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Matrix Metalloproteinase-9 as an Important Contributor to the Pathophysiology of Depression

Hongmin Li1,2, Zhaofu Sheng1,2, Suliman Khan1,2

  • 1The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Neurology
|April 4, 2022
PubMed

Insights

Matrix metalloproteinases-9 (MMP-9) may play a role in depression by influencing inflammation and brain function. Further research could establish MMP-9 as a valuable biomarker for diagnosing depression.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Background:

  • Matrix metalloproteinases (MMPs) are enzymes present in the central nervous system.
  • Elevated MMP levels are linked to various diseases.
  • MMP-9 is particularly implicated in neurological processes and inflammatory responses.

Purpose of the Study:

  • To review the potential involvement of MMP-9 in depression.
  • To explore the mechanisms through which MMP-9 may affect depression.
  • To assess MMP-9's potential as a biomarker for depression.

Main Methods:

  • Literature review of studies investigating MMP-9 and depression.
  • Analysis of research on MMP-9's roles in neuroinflammation, blood-brain barrier integrity, and synaptic plasticity.
  • Synthesis of evidence linking MMP-9 to depressive symptoms and mechanisms.

Main Results:

  • MMP-9 is implicated in inflammatory responses relevant to depression.
  • MMP-9 influences blood-brain barrier permeability and perineuronal net regulation.
  • Evidence suggests a connection between MMP-9 levels and depression.

Conclusions:

  • MMP-9 is a significant factor in neurological processes potentially underlying depression.
  • MMP-9's multifaceted roles suggest its utility as a biomarker for depression.
  • Further investigation into MMP-9 mechanisms may offer novel therapeutic targets for depression.
Keywords:
contributordepressionmatrix metalloproteinase 9 (MMP-9)minocyclineneuroplasticity

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