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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Updated: Sep 28, 2025

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
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Scurvy in the Modern World: Extinct or Not?

Fnu Amisha1, Sai Nikhila Ghanta1, Amudha Kumar1

  • 1Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA.

Cureus
|April 4, 2022
PubMed
Summary

Scurvy, a vitamin C deficiency disorder, can cause weakness, bruising, and fatigue. Early diagnosis and vitamin C supplementation are crucial for recovery, even in developed nations.

Keywords:
ascorbic acidascorbic acid deficiencycase reportrare case reportscurvyvitamin cvitamin c deficiency

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Area of Science:

  • Nutrition
  • Internal Medicine
  • Dermatology

Background:

  • Scurvy is a vitamin C deficiency disorder historically prevalent among sailors.
  • Modern advancements in nutrition have made scurvy rare in developed countries.
  • It affects skin and soft tissues, causing diverse symptoms like bleeding and musculoskeletal issues.

Observation:

  • An elderly female presented with weakness, gait instability, falls, easy bruising, fatigue, and petechial rash.
  • These symptoms were attributed to scurvy, a condition often overlooked in contemporary medicine.
  • The patient experienced symptom improvement after initiating vitamin C supplements.

Findings:

  • Vitamin C deficiency can manifest with significant constitutional and dermatological symptoms.
  • Scurvy should be considered in the differential diagnosis for petechial rash and bruising.
  • Prompt supplementation with vitamin C can effectively resolve scurvy-related symptoms.

Implications:

  • Highlights the importance of considering scurvy in elderly or at-risk populations presenting with non-specific symptoms.
  • Emphasizes the need for increased awareness among healthcare professionals regarding vitamin C deficiency.
  • Underscores the effectiveness of vitamin C supplementation in managing scurvy and its complications.