Related Experiment Video
Updated: Sep 28, 2025

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
Hemoglobinuria in the Early Poststem-Cell-Transplant Period: Risk Factors and Association with Outcomes
Panagiotis Kompotiatis1, Sandhya Manohar1, Hassan B Alkhateeb2
1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
Background:
Information on risk factors of hemoglobinuria after hematopoietic stem-cell transplant (HSCT) and its association with AKI, mortality, and engraftment is limited.
Methods:
We conducted a retrospective cohort study on all consecutive adults that underwent HSCT from January 6, 1999, to November 6, 2017. The study included 6039 patients that underwent bone marrow transplantation (BMT), umbilical cord blood, and peripheral blood stem-cell transplantation (PBSCT).
Results:
Early post-HSCT, AKI occurred in 393 (7%) patients, and 52 (0.9%) patients had post-HSCT hemoglobinuria. Post-HSCT hemoglobinuria was associated with graft type (BMT+Cord), underlying disease (lymphoma, acute leukemia), and fludarabine-based conditioning regimen. Post-HSCT hemoglobinuria was associated with early (48-72 hours) post-HSCT AKI. Graft type (BMT+Cord) was associated with AKI among patients with hemoglobinuria. AKI in patients with hemoglobinuria was associated with delayed platelet engraftment and delayed WBC engraftment but not 100-day mortality.
Conclusion:
Close monitoring is recommended in this patient group to facilitate a good engraftment outcome.
Related Concept Videos
Kidney Transplant III: Nursing Management
Kidney Transplant II: Surgical Procedure
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Kidney Transplant I: Introduction
Nephrotic Syndrome I : Introduction
Hemodialysis II: Procedure and Complications

