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Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism

Sven O Dahms1, Gisela Schnapp2, Martin Winter3

  • 1Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Straße 34, A-5020 Salzburg, Austria.

ACS Chemical Biology
|April 4, 2022
PubMed
Summary

Furin inhibitors, potent against SARS-CoV-2, bind by inducing conformational changes. This structural rearrangement creates new pockets for drug discovery, offering broad-spectrum antiviral potential.

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