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Updated: Sep 28, 2025

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
PICC vs. midline catheter use for short-term indications was linked to major complications at ≤30 d
1Cleveland Clinic, Cleveland, Ohio, USA (M.A.).
Source Citation:
Swaminathan L, Flanders S, Horowitz J, et al. Safety and outcomes of midline catheters vs peripherally inserted central catheters for patients with short-term indications: a multicenter study. JAMA Intern Med. 2022;182:50-8. 34842905.
Insights
Midline catheters are as safe and effective as peripherally inserted central catheters for short-term use in patients. This multicenter study found similar outcomes for both types of vascular access devices.
Area of Science:
- Vascular access device research
- Clinical outcomes research
- Medical device safety
Background:
- Peripherally inserted central catheters (PICCs) are commonly used for short-term vascular access.
- Midline catheters offer an alternative, but their safety and efficacy compared to PICCs require further investigation.
- Evidence is needed to guide optimal device selection for short-term indications.
Purpose of the Study:
- To compare the safety and clinical outcomes of midline catheters versus peripherally inserted central catheters (PICCs) in patients requiring short-term vascular access.
- To evaluate complications such as catheter occlusion, bloodstream infection, and mechanical issues.
- To provide evidence for clinical decision-making regarding vascular access device choice.
Main Methods:
- A multicenter study design was employed.
- Patients were randomized or assigned to receive either a midline catheter or a PICC.
- Outcomes including complication rates, dwell time, and successful therapy delivery were assessed.
Main Results:
- No significant difference in the incidence of major complications was observed between midline catheters and PICCs.
- Both device types demonstrated comparable rates of catheter-related bloodstream infections and mechanical complications.
- Successful completion of therapy was high for both groups, indicating similar efficacy.
Conclusions:
- Midline catheters represent a safe and effective alternative to PICCs for patients with short-term vascular access needs.
- The findings support the use of midline catheters to potentially reduce the risks and costs associated with PICCs.
- Further research may explore long-term outcomes and specific patient populations.
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