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Pharmacokinetic software for therapeutic drug monitoring: A scoping review protocol
Paula Del Valle-Moreno1, Pablo Ciudad-Gutiérrez1, Laura Herrera-Hidalgo1
1Pharmacy Department, Hospital Universitario Virgen del Rocío, Sevilla. Spain.. laura.herrera.sspa@juntadeandalucia.es.
Objective:
Nomograms, equations and pharmacokinetic software are considered the main tools available for therapeutic drug monitoring. Due to its great applicability to various groups of drugs, the use of software is widely extended in clinical practice. The main goals of the studies using this type of software do not normally include the description of its features, therefore, the information about its characteristic is scarce. Moreover, no review of the literature has been published that brings together all the information available about these software. The present study aimed to synthesize the available evidence regarding software applied to therapeutic drug monitoring to facilitate its identification, evaluation and election by users.
Method:
This article describe a scoping review protocol, developed following the PRISMA-P and PRISMA-ScR guidelines. An electronic literature search was performed in MEDLINE, EMBASE, OpenAire and BASE (Bielefeld Academic Search Engine) databases. Only those software for which the following information was available were included: name of the software, developer/marketer, type of pharmacokinetic analysis allowed, and drugs included in the analysis. Results: In this study we will synthesized the most relevant characteristics for the clinical practice of the pharmacokinetic software available. A critical ppraisal of the sources if information will be included. Also, if it is possible, a comparison of the available tools will be carried out in order to facilitate the evaluation and selection of pharmacokinetic software.
Conclusions:
Pharmacokinetic software has become a relevant tool for therapeutic drugs monitoring. Currently available evidence on such tools is scarce, which precludes a rapid and effective comparative analysis between the different options available. An analysis of the main characteristics and a comparison between different pharmacokinetic software will be useful to the users, leading to a greater integration of these tools in healthcare practice.
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