Evodiamine: A Privileged Structure with Broad-ranging Biological Activities.

Area of Science:

• Natural Products Chemistry
• Medicinal Chemistry
• Pharmacology

Background:

• Evodiamine (EVO), a quinolone alkaloid from Evodia rutaecarpa, has broad pharmacological activities but limited clinical use due to poor properties.
• Modification of EVO yields derivatives with enhanced potency and physicochemical properties.

Purpose of the Study:

• To provide a comprehensive review of Evodiamine derivatives.
• To focus on their diverse biological activities, mechanisms, and structure-activity relationships (SARs).

Main Methods:

• Literature review of pharmacological studies on Evodiamine derivatives.
• Analysis of reported biological activities, mechanisms of action, and SARs.
• Systematic summarization of existing research.

Main Results:

• Evodiamine derivatives exhibit significant antitumor, anti-Alzheimer's, anti-pulmonary hypertension, anti-fungal, and thermogenic activities.
• These compounds act as inhibitors or agonists for various proteins, including topoisomerases, tubulin, and HDACs.
• Diverse SARs have been identified for different biological activities.

Conclusions:

• Evodiamine derivatives represent a promising class of compounds with broad therapeutic potential.
• Further exploration of their mechanisms and SARs is warranted for drug development.
• This review serves as a valuable resource for future research on Evodiamine derivatives.