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Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association's Get With The

Kevin S Shah1, Adriana E Reyes-Miranda2, Steven M Bradley3

  • 1Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah School of Medicine, 30 N. 1900 E, Room 4A100, UT, 84132, Salt Lake City, USA. Kevin.Shah@hsc.utah.edu.

Journal of Racial and Ethnic Health Disparities
|April 5, 2022
PubMed

Insights

Black and female patients were less likely to be enrolled in COVID-19 clinical trials. This highlights disparities in healthcare access and participation for vulnerable populations during the pandemic.

Area of Science:

  • Cardiology
  • Public Health
  • Clinical Trials

Background:

  • The COVID-19 pandemic exposed significant disparities in healthcare delivery.
  • Understanding participation in clinical trials is crucial for equitable pandemic response.

Purpose of the Study:

  • To investigate disparities in clinical trial enrollment among hospitalized COVID-19 patients.
  • To determine if sex, race, and ethnicity influence trial participation.

Main Methods:

  • Analysis of data from the American Heart Association's COVID-19 CVD Registry.
  • Examined 14,397 adult patients hospitalized with COVID-19.
  • Multivariable analysis to assess odds of clinical trial enrollment based on demographics.

Main Results:

  • Overall, 9.5% of hospitalized COVID-19 patients were enrolled in clinical trials.
  • Black patients had the lowest enrollment proportion (8%).
  • Female and Black patients were significantly less likely to be enrolled compared to men and other racial groups.

Conclusions:

  • Significant disparities exist in COVID-19 clinical trial enrollment based on race and sex.
  • Further investigation is needed to identify and address the reasons for these participation gaps.
  • Ensuring equitable access to clinical trials is vital for future public health emergencies.

Keywords:
COVID-19DisparitiesEthnicityRace

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