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Updated: Sep 28, 2025

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2
B Uma Reddy1, Nanda Kishore Routhu2, Anuj Kumar3
1Department of Studies in Botany, Vijayanagara Sri Krishnadevaraya University, Ballari, 583105, India.
Introduction:
Coronavirus disease 2019 (COVID-19) is an illness caused by the new coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). It has affected public health and the economy globally. Currently approved vaccines and other drug candidates could be associated with several drawbacks which urges developing alternative therapeutic approaches.
Aim:
To provide a comprehensive review of anti-SARS-CoV-2 activities of plants and their bioactive compounds.
Methods:
Information was gathered from diverse bibliographic platforms such as PubMed, Google Scholar, and ClinicalTrials.gov registry.
Results:
The present review highlights the potential roles of crude extracts of plants as well as plant-derived small molecules in inhibiting SARS-CoV-2 infection by targeting viral or host factors essential for viral entry, polyprotein processing, replication, assembly and release. Their anti-inflammatory and antioxidant properties as well as plant-based therapies that are under development in the clinical trial phases-1 to 3 are also covered.
Conclusion:
This knowledge could further help understanding SARS-CoV-2 infection and anti-viral mechanisms of plant-based therapeutics.
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