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Updated: Sep 28, 2025

Fizzy Extraction of Volatile Organic Compounds Combined with Atmospheric Pressure Chemical Ionization Quadrupole Mass Spectrometry
Published on: July 14, 2017
Direct Mass Spectrometric Analysis of Semivolatiles Derived from Real Samples at Atmospheric Pressure
De-Yi Huang1,2, Jia-Jen Tsai1,2, Yu-Chie Chen1,2,3
1Department of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Abstract:
This study demonstrated a facile ionization method with the use of real samples for the ionization of their main compositions at ambient conditions for mass spectrometric analysis. Analyte ions derived from the real samples were readily observed in the mass spectrum when placing the samples close (≤1 mm) to the inlet of the mass spectrometer applied with a high voltage. No additional accessories such as an ionization emitter, a plasma generator, or a high voltage power supply were required for this approach. Ionization of semivolatiles derived from the samples occurred between the samples and the inlet of the mass spectrometer presumably owing to the dielectric breakdown induced by the electric field provided by the mass spectrometer. Real samples including plants, medicine tablets, and gloves with contaminants were used as the model samples. The putative ionization mechanisms are also discussed in this study.
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