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Updated: Sep 28, 2025

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Complementary therapies for patients with systemic sclerosis.

Kimberly Showalter1,2, Aileen Hoffmann1, Nicole DeCredico1

  • 1Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Journal of Scleroderma and Related Disorders
|April 6, 2022
PubMed
Summary
This summary is machine-generated.

Patients with systemic sclerosis may benefit from complementary therapies like vitamins D and E, probiotics, and acupuncture. Further research is needed to confirm these findings for systemic sclerosis (SSc) care.

Keywords:
Systemic sclerosisalternative therapyautoimmune diseasecomplementary therapycurcumindietary supplementnutritionvitamin Dvitamin E

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Area of Science:

  • Rheumatology
  • Integrative Medicine
  • Clinical Nutrition

Background:

  • Systemic sclerosis (SSc) is a chronic autoimmune disease.
  • Patients frequently explore complementary and nutrition-based therapies for symptom management.
  • Evidence for these therapies in SSc is often limited.

Purpose of the Study:

  • To review current data on complementary therapies for systemic sclerosis.
  • To summarize potential benefits of nutrition-based interventions.
  • To provide recommendations for SSc patient care.

Main Methods:

  • Literature review of existing studies.
  • Analysis of data on vitamins, probiotics, turmeric, and other supplements.
  • Inclusion of mind-body and physical therapies like acupuncture and biofeedback.

Main Results:

  • Vitamins D and E, probiotics, turmeric, l-arginine, essential fatty acids, broccoli, biofeedback, and acupuncture show potential benefits.
  • Limited large-scale randomized clinical trials exist for these interventions in SSc.
  • Current data suggests a possible role for these therapies in managing SSc.

Conclusions:

  • Complementary and nutrition-based therapies warrant consideration in systemic sclerosis management.
  • Further high-quality clinical trials are necessary to validate efficacy and safety.
  • Recommendations are provided for integrating these therapies into SSc care.