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Factors associated with COVID-19 lethality in a hospital in the Cajamarca region in Peru

Walter Anyaypoma-Ocón1, Sandra Ñuflo Vásquez1, Hugo Cesar Bustamante-Chávez2

  • 1Oficina de Epidemiología. Dirección Regional de Salud Cajamarca (DIRESA Cajamarca), Cajamarca, Perú.

Revista Peruana De Medicina Experimental Y Salud Publica
|April 6, 2022
PubMed

Insights

Older age, low oxygen saturation, and ICU bed requests were linked to higher COVID-19 in-hospital deaths. Ivermectin use also showed an association with increased lethality in hospitalized patients.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • COVID-19 remains a significant global health concern, necessitating ongoing research into factors influencing patient outcomes.
  • Understanding in-hospital lethality is crucial for optimizing resource allocation and patient management strategies.

Purpose of the Study:

  • To determine clinical and epidemiological characteristics associated with in-hospital mortality among COVID-19 patients.
  • To identify risk factors for severe outcomes in hospitalized COVID-19 cases.

Main Methods:

  • Retrospective cohort study utilizing clinical records and epidemiological surveillance data.
  • Analysis included sociodemographic and clinical factors, with outcomes of death or survival and hospitalization duration.

Main Results:

  • The in-hospital fatality rate was 39.6%.
  • Factors significantly associated with increased lethality included age over 60, unattended ICU bed requests, oxygen saturation below 80% on admission, and ivermectin use.
  • Machine learning models identified oxygen saturation, age, hospitalization time, and symptom onset time as key predictors.

Conclusions:

  • Age, low oxygen saturation, ivermectin treatment, and unmet ICU bed needs are potential contributors to COVID-19 lethality.
  • Further research with broader scope is recommended to validate these findings regionally and nationally.
Abstract

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