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RNA-binding proteins in diabetic microangiopathy.
Chao Tu1, Liangzhi Wang1, Lan Wei1
1Department of Internal Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Journal of Clinical Laboratory Analysis
|April 6, 2022
Summary
RNA binding proteins (RBPs) are key players in diabetic microangiopathy, impacting diabetic retinopathy and nephropathy. Research shows RBPs offer potential as therapeutic targets and diagnostic markers for these diabetes complications.
Area of Science:
- Molecular Biology
- Endocrinology
- Ophthalmology
Background:
- Diabetic microangiopathy, encompassing diabetic retinopathy (DR) and nephropathy (DN), is a major complication of diabetes.
- RNA binding proteins (RBPs) are crucial for cellular processes and implicated in diabetes pathogenesis.
Purpose of the Study:
- To review the role of RBPs in diabetic retinopathy and nephropathy.
- To explore the therapeutic and diagnostic potential of RBPs in diabetic microangiopathy.
Main Methods:
- Literature review of studies on RBPs in diabetic microangiopathy.
- Analysis of RBP involvement in DR and DN pathogenesis and progression.
Main Results:
- RBPs demonstrate potential as therapeutic targets, diagnostic markers, and predictors of disease progression in diabetic microangiopathy.
- Specific RBPs like HuR are highlighted for their therapeutic potential in diabetic microangiopathy.
Conclusions:
- HuR is a vital therapeutic target for diabetic microangiopathy.
- IGF2BP2, P311, TTP, YBX1, and MBNL1 show promise for treating diabetic nephropathy (DN).
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