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Related Experiment Video

Updated: Sep 28, 2025

Construction of a Wireless-Enabled Endoscopically Implantable Sensor for pH Monitoring with Zero-Bias Schottky Diode-based Receiver

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Published on: August 27, 2021

Ionic communication for implantable bioelectronics.

Zifang Zhao¹, George D Spyropoulos¹, Claudia Cea¹

¹Department of Electrical Engineering, Columbia University, New York, NY 10027, USA.

Science Advances

|April 6, 2022

Summary

This summary is machine-generated.

Ionic communication (IC) transmits data through tissue using ions, enabling megahertz-range signals for bioelectronic devices. This novel method allows stable, long-term, high-fidelity neural data transmission from implantable devices.

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Area of Science:

Bioelectronic devices
Biomedical engineering
Neuroscience

Background:

Implanted bioelectronic devices face challenges in data transmission through biological tissue due to its ionic conductivity and inhomogeneity.
Conventional communication methods are complicated by the complex nature of biological tissues.

Purpose of the Study:

To introduce and validate a novel data transmission method called ionic communication (IC) for implanted bioelectronic devices.
To demonstrate the feasibility of transmitting high-frequency signals through biological tissues using ions.

Main Methods:

Developed ionic communication (IC) utilizing ion propagation for megahertz-range signal transmission.
Demonstrated IC's operation via generation and sensing of electrical potential energy in polarizable media.
Tuned IC for transmission across various biologically relevant tissue depths and controlled propagation radius for parallel communication.

Main Results:

Successfully transmitted megahertz-range signals through biological tissue using IC.
Achieved controlled propagation radius for multiline parallel communication without interfering with other bioelectronics.
Developed a fully implantable IC-based neural interface device for stable, long-term neurophysiologic data acquisition and transmission in rodents, isolating action potentials from individual neurons.

Conclusions:

Ionic communication (IC) offers a biologically based solution for data transmission across intact tissue.
IC enables long-term, high-fidelity interactions for implanted bioelectronic devices, overcoming limitations of conventional methods.
This technology paves the way for advanced neural interfaces and bioelectronic systems.