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Study Protocol: Multimodal Longitudinal Assessment of Infant Brain Organization and Recovery in Perinatal Brain

Catarina Saiote1, Ellen Sutter, Annette Xenopoulos-Oddsson

  • 1Waisman Center (Drs Saiote, Sutter, Dean, and Gillick), Department of Pediatrics (Drs Dean, McAdams, and Gillick), and Department of Medical Physics (Dr Dean), University of Wisconsin-Madison, Madison, Wisconsin; Department of Rehabilitation Medicine (Dr Sutter and Ms Xenopoulos-Oddsson), Department of Pediatrics (Drs Rao and Georgieff), and Division of Biostatistics (Dr Rudser), University of Minnesota, Minneapolis, Minnesota; Department of Physical Therapy and Human Movement Sciences, Department of Pediatrics (Dr Peyton), Northwestern University, Chicago, Illinois.

Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association
|April 6, 2022
PubMed

Insights

This study introduces a new method to track infant brain development after perinatal injury. It aims to find early signs of motor function recovery and neuroplasticity to improve diagnosis and treatment.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pediatric Neurology

Background:

  • Perinatal brain injury is a leading cause of cerebral palsy, leading to lifelong motor deficits.
  • The corticospinal tract (CST) is crucial for motor control and develops significantly during infancy.
  • The relationship between perinatal injury recovery, CST development, and infant motor outcomes remains unclear.

Purpose of the Study:

  • To establish a protocol for multimodal longitudinal assessment of brain development and motor function in infants with perinatal brain injury.
  • To investigate the functional and structural integrity of the CST using noninvasive techniques.
  • To explore the links between cortical excitability, CST integrity, and motor function in infants.

Main Methods:

  • Utilizing transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI) for noninvasive CST assessment.
  • Conducting longitudinal evaluations in infants aged 3 to 24 months.
  • Correlating neuroimaging and neurophysiological data with detailed motor function assessments.

Main Results:

  • The protocol allows for the identification of key bioindicators of motor outcome.
  • It provides insights into the neuroplasticity of the developing brain following injury.
  • Preliminary findings suggest associations between CST integrity and motor performance.

Conclusions:

  • This multimodal approach can identify bioindicators for motor outcomes and neuroplasticity in infants with perinatal brain injury.
  • The findings will inform early detection, diagnosis, and intervention strategies.
  • This research has the potential to significantly improve the management of conditions like cerebral palsy stemming from perinatal events.
Abstract

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