[Changes of coagulation function in patients with adenomyosis]

Area of Science:

• Gynecology
• Hematology
• Pathophysiology

Background:

• Adenomyosis is a gynecological condition characterized by the presence of endometrial tissue within the myometrium.
• Coagulation abnormalities have been anecdotally reported in adenomyosis patients, but comprehensive analysis is lacking.

Purpose of the Study:

• To investigate the coagulation state in patients with adenomyosis.
• To determine the clinical significance of these coagulation differences.

Main Methods:

• Retrospective analysis of clinical data from adenomyosis patients and controls.
• Comparison of coagulation indexes (fibrinogen, D-dimer, prothrombin time, etc.) during menstrual and non-menstrual periods.
• Correlation analysis of coagulation indexes with clinical parameters like CA125, CA19-9, and uterine volume.

Main Results:

• Patients with adenomyosis showed significantly higher fibrinogen and D-dimer levels during the menstrual period compared to the non-menstrual period.
• Elevated D-dimer and platelet counts were observed in adenomyosis patients compared to controls with cervical intraepithelial neoplasia grade III during the non-bleeding period.
• Coagulation indexes correlated significantly with CA125, CA19-9, and uterine volume, and were altered in anemic patients.

Conclusions:

• Adenomyosis patients exhibit a hypercoagulable state during both uterine bleeding and non-bleeding phases.
• This hypercoagulability may be associated with increased uterine volume, elevated serum CA125, and the presence of anemia.