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Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy
Shuyan Han1, Jun Wu1
1School of Biomedical Engineering, Sun Yat-sen University, Shenzhen, 518057, China.
Bioactive Materials
|April 7, 2022
Summary
Biomaterial scaffolds with 3D structures enhance cancer immunotherapy by enabling localized delivery of agents. These scaffolds offer a promising strategy to boost antitumor immunity while minimizing systemic toxicities.
Area of Science:
- Biomaterials science
- Immunology
- Oncology
Background:
- Cancer immunotherapy has seen success but faces challenges.
- Biomaterial-based strategies are emerging to enhance antitumor immunity.
- Macroscale 3D scaffolds offer advantages for localized immunotherapy.
Purpose of the Study:
- To review recent advances in 3D biomaterial scaffolds for cancer immunotherapy.
- To discuss the design requirements and impact of these scaffolds on antitumor immunity.
- To explore future perspectives in scaffold-assisted local cancer treatment.
Main Methods:
- Literature review of recent achievements in 3D scaffold development for cancer immunotherapy.
- Analysis of physicochemical and biological properties of scaffolds.
- Discussion of scaffold-mediated immunomodulation and antitumor effects.
Main Results:
- 3D biomaterial scaffolds facilitate encapsulation, localized delivery, and controlled release of immunotherapeutic agents.
- Scaffolds can minimize systemic toxicities while promoting abscopal effects.
- Scaffold properties (porosity, stiffness, surface modification, etc.) significantly influence immunotherapeutic outcomes.
Conclusions:
- 3D biomaterial scaffolds are effective niches for cancer immunotherapy.
- Understanding scaffold-biomaterial interactions is crucial for optimizing antitumor immune responses.
- Future research should focus on rational design of 3D scaffolds for improved in situ cancer immunotherapy.
