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Updated: Sep 27, 2025

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
Parry Romberg disease with En Coup de Sabre Scleroderma: Effect of tocilizumab on periodontal bone inflammation
Thaís Cugler Meneghetti1, Juliana Yassue Barbosa da Silva2, Lúcio Eduardo Kluppel3
1Unit of Pediatric Rheumatology, Waldemar Monastier Children's Hospital and Clinics Hospital, Federal University of Paraná, Curitiba, Brazil.
Abstract:
Parry Romberg disease and En Coupe de Sabre Scleroderma are frequently associated disorders that affect the face and can cause severe aesthetic and functional impairment. Systemic immunosuppression is the gold standard of first-line treatment in the pediatric rheumatology standpoint although it is often delayed in the pediatric dermatology clinics and more often used in cases of refractory neurological impairment. We report on a case with dental root resorption and severe periodontal bone inflammation detected on magnetic resonance imaging, which was successfully treated with the anti-IL-6 agent tocilizumab.
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