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Updated: Sep 27, 2025
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Preoperative Stereotactic Body Radiation Therapy for Soft-Tissue Sarcoma: Results of Phase 2 Study
Gregory J Kubicek1, Tae Won Kim2, Christina J Gutowski2
1Department of Radiation Oncology, Cooper University Hospital, Camden, New Jersey.
Purpose:
Preoperative radiation followed by surgical resection is a standard treatment for soft-tissue sarcomas (STS). We report on 2 consecutive, phase 2, single-arm studies evaluating 5 fraction stereotactic body radiation therapy (SBRT) treatments followed by surgical resection for STS (clinical trails.gov NCT02706171).
Methods And Materials:
A total of 16 patients were treated with preoperative SBRT. Tumor size in the greatest dimension was a median 6.7 cm (maximum: 14 cm) and the majority of STS were in the extremities. SBRT consisted of 35 to 40 Gy in 5 fractions every other day.
Results:
Median follow-up time was 1719 days (4.7 years). Grade ≥3 acute toxicity occurred in 1 patient (grade 3 skin changes). Fifteen patients proceeded with surgical resection. Three patients had a wound complication after surgery, 1 patient had grade ≥3 late toxicity (grade 4 requiring surgical intervention). There was 1 local recurrence and 5 distant recurrences.
Conclusions:
Long-term follow-up on SBRT for STS found acceptable control and toxicity rates, and warrants further evaluation.
