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The eosinophilic leukocyte: structure and function.

G J Gleich, C R Adolphson

    Advances in Immunology
    |January 1, 1986
    PubMed
    Summary
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    Eosinophils combat helminths using oxidants and cationic proteins, and regulate inflammation in diseases like asthma. These cells may also initiate inflammatory responses and play a role in reproduction.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Eosinophils are immune cells with known roles in parasitic infections and inflammatory diseases.
    • Mast cells are traditionally considered central to allergic inflammation.

    Purpose of the Study:

    • To review the evidence for eosinophil functions in helminth killing and inflammation.
    • To explore the potential role of eosinophils in initiating inflammatory responses.

    Main Methods:

    • Review of existing scientific literature on eosinophil functions.
    • Analysis of eosinophil interactions with other immune cells and mediators.

    Main Results:

    • Eosinophils effectively kill helminths via oxidants and cationic proteins, regulated by mast cells, monocytes, and T lymphocytes.

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  • Eosinophils contribute to inflammation in asthma, skin, and heart diseases.
  • Eosinophils bind IgE and release inflammatory mediators, suggesting a role in initiating inflammation.

    • Conclusions:

    • Eosinophils are potent effectors against helminths and key players in inflammatory diseases.
    • Eosinophils may initiate inflammatory responses, challenging the traditional view of mast cell dominance.
    • Eosinophil-related proteins have an uncharacterized role in human reproduction.