A covalent organic framework with a self-contained light source for photodynamic therapy
Wen-Xiu Ren1, Fei Kong1, Yu-Qing Shao1
1College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education Shandong Normal University, Jinan 250014, People's Republic of China. Jiefeng@sdnu.edu.cn.
Chemical Communications (Cambridge, England)
|April 7, 2022
Summary
A novel covalent organic framework (COF)-based nanosystem enables light-independent photodynamic therapy (PDT) for cancer. This system effectively combats tumors in models with and without high hydrogen peroxide levels.
Area of Science:
- Materials Science
- Nanotechnology
- Oncology
Background:
- Photodynamic therapy (PDT) typically requires external light activation.
- Developing light-independent antitumor strategies is crucial for broader clinical application.
- Hydrogen peroxide (H2O2) levels vary significantly across different tumor microenvironments.
Purpose of the Study:
- To develop a covalent organic framework (COF)-based host-guest nanosystem for external light-independent antitumor photodynamic therapy (PDT).
- To evaluate the efficacy of the COF-based nanosystem in diverse tumor models, including those with low H2O2 expression.
Main Methods:
- Fabrication of a COF-based host-guest nanosystem.
- In vitro and in vivo evaluation of the nanosystem's antitumor efficacy.
- Assessment of therapeutic outcomes in H2O2-overexpressed (4T1) and H2O2-less (HCT116, MCF-7) xenograft models.
Main Results:
- Successful realization of external light-independent antitumor PDT using the COF-based nanosystem.
- Demonstration of highly effective antitumor behavior across different xenograft models.
- The nanosystem exhibits potent therapeutic effects regardless of endogenous H2O2 levels.
Conclusions:
- The developed COF-based host-guest nanosystem represents a promising platform for light-independent antitumor PDT.
- This approach overcomes the limitations of traditional PDT, offering a versatile therapeutic strategy.
- The system's efficacy in H2O2-deficient tumors highlights its potential for treating a wider range of cancers.
