Sulphur ylide-mediated cyclopropanation and subsequent spirocyclopropane rearrangement reactions
Qing-Song Dai1,2,3, Jun-Long Li4,2, Qi-Wei Wang1,4,2
1Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China. wqw@cioc.ac.cn.
Abstract:
The efficient construction of cyclopropyl spiroindoline skeletons and the exploration of related follow-up synthetic transformations have elicited considerable interest amongst members of the chemistry community. Here, we describe a formal (2 + 1) annulation and three-component (1 + 1 + 1) cascade cyclisation via sulphur ylide cyclopropanation under mild conditions. The spiro-cyclopropyl iminoindoline moiety can be readily transformed into another medicinally interesting pyrrolo[3,4-c]quinoline framework through a novel rearrangement process.
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