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Rheopheresis: A narrative review.
1AURA Sante, Pole Santé République, Clermont Ferrand, France.
The International Journal of Artificial Organs
|April 7, 2022
Summary
Rheopheresis, a blood filtration method, removes harmful proteins to improve microcirculation. This extracorporeal procedure shows promise for conditions like age-related macular degeneration and peripheral artery disease.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Ophthalmology
Background:
- Rheopheresis is an extracorporeal selective double-filtration procedure.
- It removes high molecular weight proteins such as LDL, Lp(a), fibrinogen, α2-macroglobulin, Factor von Willebrand, and IgM Immunoglobulin from blood plasma.
- These proteins can negatively impact microcirculation and rheologic parameters.
Purpose of the Study:
- To review the available data on the effects of Rheopheresis in various clinical conditions.
- To evaluate Rheopheresis as a therapeutic option for diseases characterized by impaired microcirculation.
Main Methods:
- This study is a narrative review of existing literature.
- The review discusses data on the clinical applications and outcomes of Rheopheresis.
Main Results:
- Rheopheresis demonstrates a rapid effect in clinical conditions with severely affected microcirculation and rheologic parameters.
- Positive effects are noted in dry age-related macular degeneration (AMD), sudden sensorineural hearing loss (SSHS), peripheral artery disease (PAD), calciphylaxis, systemic sclerosis, and diabetic foot.
Conclusions:
- Rheopheresis is a promising therapeutic technique.
- It is particularly effective for conditions involving compromised microcirculatory rheologic parameters.
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