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Updated: Sep 27, 2025

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
CoH-catalyzed radical hydroalkylation of alkenes with 1,3-dicarbonyls
Meihui Guan1, Huanran Miao1, Tao Qin1
1Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China. zhangg492@nenu.edu.cn.
Abstract:
Metal-hydride hydrogen atom transfer (MHAT) catalysis has emerged as a useful reaction platform for alkene hydrofunctionalization with high chemoselectivity and predictable branched selectivity. However, MHAT-mediated hydrofunctionalization involves carbon-carbon bond formation still confined to carbon electrophiles. Here, we describe a mild, general, scalable, and functional group tolerant CoH-catalyzed intermolecular hydroalkylation of alkenes with 1,3-dicarbonyls. This kind of CoH-catalyzed coupling of alkenes with carbon nucleophiles represents an important complement to the arsenal of MHAT-initiated hydrofunctionalization of alkenes.
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