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Updated: Sep 27, 2025

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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Association Between Meniere Disease and Migraine
So Young Kim1, Chang Ho Lee1, Dae Myoung Yoo2
1Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
JAMA Otolaryngology-- Head & Neck Surgery
|April 7, 2022
Summary
Individuals with Meniere disease (MD) have a significantly higher risk of developing migraine. Conversely, those with migraine also face an increased risk of developing MD, indicating a strong bidirectional link.
Area of Science:
- Otolaryngology
- Neurology
- Epidemiology
Background:
- A potential link between Meniere disease (MD) and migraine has been suggested.
- However, the temporal relationship and bidirectional nature of this association remain unclear.
Purpose of the Study:
- To investigate the bidirectional association between Meniere disease and migraine.
Main Methods:
- A population-based case-control study utilizing data from the Korean National Health Insurance Service Health Screening Cohort (2002-2015).
- Two cohorts were analyzed: patients with MD (n=6919) and patients with migraine (n=35,889), each matched with controls.
- Stratified Cox proportional hazard regression models were used to assess the incidence of migraine in MD patients and MD in migraine patients.
Main Results:
- Patients with MD showed a 2.22-fold increased risk of developing migraine compared to controls.
- Patients with migraine demonstrated a 1.95-fold increased risk of developing MD compared to controls.
- Both conditions exhibited a statistically significant bidirectional association.
Conclusions:
- This study confirms a significant bidirectional relationship between Meniere disease and migraine.
- The findings suggest that shared underlying mechanisms may link these two conditions.
- Therapeutic strategies targeting one condition might offer benefits for the other, warranting further investigation.
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