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[D-penicillamine and collagen].

J P Camus, A C Koeger

Annales De Biologie Clinique

|January 1, 1986

Summary

This summary is machine-generated.

D-penicillamine is a medication used for conditions like Wilson's disease and rheumatoid arthritis. It affects collagen, leading to side effects and therapeutic benefits in fibrotic diseases.

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Area of Science:

Pharmacology
Biochemistry
Toxicology

Context:

D-penicillamine is a chelating agent and drug with diverse clinical applications.
Its mechanism involves interactions with collagen and other connective tissue components.

Purpose:

To elucidate the dual role of D-penicillamine as an osteolathyrogenic agent and a collagen-modulating therapeutic.
To correlate its biochemical effects with observed clinical side effects and treatment benefits.

Summary:

D-penicillamine exhibits osteolathyrogenic properties, potentially explaining side effects like fetal dysplasias, impaired wound healing, skin lesions, bronchiolitis, and autoimmune disorders.
Conversely, its impact on collagen synthesis and cross-linking underpins its therapeutic efficacy in fibrotic conditions, including systemic sclerosis and liver or lung fibrosis.

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Impact:

Understanding D-penicillamine's collagen-related effects is crucial for managing its side effects and optimizing its use in treating fibrotic diseases.
This knowledge aids in developing safer and more effective therapeutic strategies for connective tissue disorders.