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Botulinum Toxin in Hidradenitis Suppurativa: A Systematic Review
Journal of Drugs in Dermatology : JDD
|April 7, 2022
Summary
Botulinum toxin shows promise as a safe and effective treatment for hidradenitis suppurativa, particularly for patients resistant to other therapies. Further high-quality research is needed to confirm its therapeutic potential.
Area of Science:
- Dermatology
- Medical Therapeutics
Background:
- Hidradenitis suppurativa (HS) disproportionately impacts women, minorities, and individuals with skin of color.
- Limited literature exists on botulinum toxin as a treatment for HS.
- Botulinum toxin is being explored as a potential therapy for HS.
Purpose of the Study:
- To analyze existing evidence on the use of botulinum toxin for treating hidradenitis suppurativa.
- To evaluate the efficacy and safety of botulinum toxin in HS management.
Main Methods:
- A systematic literature search was conducted across PubMed, Embase, and Cochrane Library.
- Studies published up to June 10, 2020, were included.
- Review articles, meta-analyses, and studies lacking published results were excluded.
Main Results:
- Seven studies met the inclusion criteria for the review.
- Botulinum toxin treatment led to clinical improvement or enhanced quality of life in 96.8% of patients (30/31).
- The overall level of evidence for these studies was moderate.
Conclusions:
- Botulinum toxin represents a safe and potentially effective alternative therapy for hidradenitis suppurativa patients who are refractory to standard treatments.
- Dermatologists should consider this therapeutic option for patients with limited treatment responses.
- High-quality investigations are recommended to further establish the therapeutic role of botulinum toxin in HS.
