Choroidal thickness in patients with alopecia areata: Is it a sign for poor prognosis?

Alopecia areata (AA) is an autoimmune disease which causes non-scarring type hair loss considered to target the pigmentary system. The hair follicle may not be the only site for involvement of the disease. Iris, the ciliary body, choroid and epithelium of the retinal pigment may also be affected. The aim of the present study was to compare retinal pigment epithelium (RPE) and choroidal thicknesses between patients with AA and healthy controls.

The study included 44 patients with alopecia areata, and 44 healthy individuals with similar age and gender distribution. RPE and choroidal thickness measurements were performed through Spectral-domain optical coherence tomography (SD-OCT) (Heidelberg Spectralis^® OCT).

There was not any significant difference between patients with AA and healthy individuals for RPE and choroidal thickness (p = 0.751, p = 0.725, respectively). However, the choroidal thickness (422 ± 79 μm) was significantly thinner in patients with poor prognostic criteria than other patients (371 ± 75 μm; p = 0.039).

Monitoring of choroidal thicknesses through optic coherence tomography (OCT) may provide an insight for the disease prognosis in patients with AA.