The Relationship Between Systemic Immune Inflammatory Level and Dry Eye in Patients with Sjögren's Syndrome

Area of Science:

• Immunology
• Rheumatology
• Ophthalmology

Background:

• Sjögren Syndrome (SS) is a chronic autoimmune disease characterized by inflammation.
• Dry eye and dry mouth affect nearly all patients with primary SS (pSS).
• Inflammatory processes are key in SS pathogenesis.

Purpose of the Study:

• To investigate the correlation between the Systemic Immune-Inflammation Index (SII) and disease activity in pSS patients.
• To assess the relationship between SII and dry eye involvement in pSS.
• To evaluate hematological parameters in pSS patients.

Main Methods:

• Cross-sectional study involving 28 female pSS patients (age 18-65).
• Calculated Sjögren Syndrome Disease Activity Index (ESSDAI) for disease activity assessment.
• Utilized Schirmer test and Ocular Surface Disease Index (OSDI) for dry eye evaluation.

Main Results:

• A strong positive correlation was observed between SII levels and pSS disease activity.
• The Schirmer test showed a negative correlation with eye drying time, indicating dry eye.
• A positive correlation was found between SII and OSDI scores.

Conclusions:

• Hematological parameters, including SII, correlate with dry eye development in pSS.
• Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII demonstrated significant changes in pSS patients.
• SII may serve as a valuable indicator for disease activity and dry eye in Sjögren Syndrome.