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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
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Refractory Methamphetamine-Induced Psychosis: An Emerging Crisis in Rural America and the Role of Amantadine in

Mayank Gupta1,2, Nihit Gupta3, Michael Esang4

  • 1Psychiatry, Lake Erie College of Osteopathic Medicine, Erie, USA.

Cureus
|April 8, 2022
PubMed

Insights

Methamphetamine (MA) use has risen in rural areas, partly due to opioid restrictions. This increase strains mental health services with complex psychosis cases, requiring updated clinical understanding.

Area of Science:

  • Public Health
  • Neuroscience
  • Psychiatry

Background:

  • Methamphetamine (MA) use has significantly increased in rural America over the past decade.
  • This trend is linked to reduced opioid availability following interventions for the opioid epidemic.
  • Emergence of cheaper alternatives like fentanyl-laced fake prescriptions exacerbates the substance abuse crisis.

Observation:

  • Methamphetamine use is associated with a serious clinical effect: psychosis.
  • Atypical presentations and refractory courses of MA-induced psychosis challenge clinicians.
  • Mental health services are increasingly stretched due to these complex cases.

Findings:

  • Understanding the unique pharmacodynamics and neurotoxicity of MA is critical.
  • Recognizing similarities between MA psychosis and schizophrenia is essential for diagnosis.
  • Evolving empirical evidence highlights the complexity of managing MA-induced psychosis.

Implications:

  • Clinicians need updated knowledge to address the growing challenge of MA psychosis.
  • Effective management strategies for methamphetamine-induced psychosis require further research.
  • Addressing the rural mental health and substance abuse crisis necessitates tailored interventions for MA use.
Keywords:
amantadinemethmethamphetaminepsychosisrural

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