Related Experiment Video

Updated: Sep 27, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

50.5K

Bronchopulmonary dysplasia is associated with polyhydramnios in a scan for novel perinatal risk factors

Meredith S Campbell1, Lisa A Bastarache2, Sara L Van Driest1

  • 1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

Pediatric Research
|April 8, 2022
PubMed

Insights

Polyhydramnios, or excess amniotic fluid, is linked to a higher risk of bronchopulmonary dysplasia in premature infants. This finding aids in identifying high-risk newborns for better care.

Area of Science:

  • Neonatal Medicine
  • Perinatal Epidemiology

Background:

  • Bronchopulmonary dysplasia (BPD) pathogenesis is complex with limited data on prenatal risk factors.
  • Identifying prenatal exposures associated with BPD is crucial for early intervention.

Purpose of the Study:

  • To investigate the association between prenatal exposures and the risk of developing BPD.
  • To evaluate polyhydramnios as a potential clinical indicator for BPD risk.

Main Methods:

  • Parallel analyses using a logistic regression model on a curated registry of 4527 infants.
  • Phenome-wide association study (PheWAS) using ICD-9/10 codes to analyze 94 maternal diagnosis phecodes.
  • Examined 20 prenatal exposures from a neonatal intensive care unit (NICU) registry.

Main Results:

  • Polyhydramnios showed a significant association with increased BPD risk in both registry and PheWAS analyses (OR 5.70, p < 1.37×10⁻⁶).

Conclusions:

  • Polyhydramnios may serve as a clinical indicator for preterm infants at elevated risk of BPD.
  • Combining curated registry data with PheWAS analysis is a valuable tool for generating hypotheses on perinatal risk factors.
Abstract

More Related Videos

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure05:50

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure

Published on: March 12, 2020

13.8K
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.5K

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
365
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
486
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
304
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.6K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.9K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.7K