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Updated: Sep 27, 2025
Differentiation of Human Pluripotent Stem Cells Into Pancreatic Beta-Cell Precursors in a 2D Culture System
Published on: December 16, 2021
Stem cell-derived β cells go in monkeys
Anne Grapin-Botton1, Barbara Ludwig2
1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at The University Hospital Carl Gustav Carus and Faculty of Medicine of the Technische Universität Dresden, Dresden 01307, Germany.
Abstract:
Du et al. transplanted β cells derived from pluripotent stem cells in diabetic monkeys for the first time, as an intermediate stage toward clinical translation. They observed benefits unfolding over months but also observed immune rejection of the grafts by 5-6 months.
