Related Experiment Video
Updated: Apr 24, 2026

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
Published on: May 17, 2024
Rethinking HNF1A-MODY: HNF1A at the crossroads of development and multiorgan metabolic disease
Julie Warin1, Anne Grapin-Botton2,3,4,5,6
1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany.
None:
In this issue of Genes & Development, Unger and colleagues (doi:10.1101/gad.353153.125) combined human pluripotent stem cell-derived in vitro models with targeted in vivo mouse models to reveal multiple developmental defects triggered by HNF1A mutations causing maturity-onset diabetes of the young. This work paints the picture of a disorder that starts well before diabetes manifests, highlighting its complexity arising from the diverse roles of HNF1A across distinct cell types, each potentially differentially impacted by different mutations.
Related Concept Videos
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Huntington Disease l: Introduction
Inborn Errors of Metabolism
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...

