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Vinpocetine (A comprehensive profile).

Nasr Y Khalil1, Ahmed H Bakheit2, Hamad M Alkahtani1

  • 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology
|April 9, 2022
PubMed
Summary
This summary is machine-generated.

Vinpocetine, a periwinkle extract, offers cognitive and memory enhancement benefits for neurological disorders. This profile details its properties, analysis, and clinical applications.

Keywords:
Clinical applicationsDrug profileMethods of analysisPharmacokineticsPreparationPropertiesVinpocetine

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Area of Science:

  • Pharmacology and Phytochemistry
  • Neuroscience
  • Analytical Chemistry

Background:

  • Vinpocetine (VIN) is a herbal supplement derived from the periwinkle plant, recognized for its multi-action therapeutic potential.
  • It is utilized for neurological conditions like Alzheimer's and Parkinson's disease, and also possesses anti-inflammatory, analgesic, and antioxidant properties.
  • Vinpocetine is increasingly marketed as a dietary supplement for cognitive and memory enhancement.

Purpose of the Study:

  • To comprehensively profile Vinpocetine, detailing its physicochemical characteristics, preparation methods, and impurity profiles.
  • To review and discuss various analytical methodologies for Vinpocetine, including compendial, electrochemical, spectrophotometric, and chromatographic techniques.
  • To examine the stability of Vinpocetine under various stress conditions and to discuss its clinical applications, uses, side effects, dosing, pharmacokinetics, and mechanism of action.

Main Methods:

  • Physicochemical characterization and impurity profiling.
  • Review of analytical methods: Compendial, Electrochemical, Spectrophotometric, and Chromatographic.
  • Stability studies under acidic, alkaline, and photolytic stress conditions.

Main Results:

  • Detailed physicochemical properties and spectroscopic behavior of Vinpocetine are elucidated.
  • Various analytical techniques for Vinpocetine quantification and quality control are discussed.
  • Stability data under stress conditions provides insights into degradation pathways.

Conclusions:

  • Vinpocetine exhibits diverse pharmacological properties beneficial for neurological health and cognitive function.
  • A thorough understanding of its analytical methods and stability is crucial for its effective and safe application.
  • This profile serves as a comprehensive resource on Vinpocetine for researchers and clinicians.