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Mitochondrial-to-nuclear communication in aging: an epigenetic perspective
1State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100093, China.
Trends in Biochemical Sciences
|April 10, 2022
Summary
Mitochondria signal to the nucleus, influencing epigenetics and aging. Understanding this mitochondrial-to-nuclear communication offers new pathways to promote longevity and healthspan.
Area of Science:
- Mitochondrial biology and epigenetics
- Cellular signaling in aging
Background:
- Mitochondria play a crucial role in aging beyond energy production.
- Mitochondria act as signaling organelles, communicating cellular fitness to the nucleus.
- This communication influences transcriptional programs vital for homeostasis and organismal health.
Purpose of the Study:
- To summarize recent findings on mitochondrial-to-nuclear (mito-nuclear) communication.
- To elucidate mechanisms by which mito-nuclear communication modulates epigenomes.
- To explore the effects of these epigenetic changes on regulating the aging process.
Main Methods:
- Review of emerging studies on mito-nuclear communication.
- Analysis of how mitochondrial metabolites and stress signals impact epigenetic modifications.
- Investigation of the link between these epigenetic changes and aging regulation.
Main Results:
- Mito-nuclear communication involves altered mitochondrial metabolites and stress signals.
- These signals induce epigenetic changes that aid in maintaining homeostasis.
- Dysregulation of this communication impacts the aging process.
Conclusions:
- Mitochondrial metabolites can act as prolongevity signals.
- Understanding aging's effect on mito-nuclear communication is key.
- Targeting this communication pathway may lead to interventions for promoting longevity and healthspan.
Keywords:
UPR(mt)agingepigenetic regulationlongevitymitochondrial metabolitesmitochondrial–nuclear communicationMore Related Videos
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