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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: Sep 27, 2025

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

Published on: January 26, 2024

Inflammation and hematopoietic stem cells aging.

Hanqing He¹, Jianwei Wang¹

¹School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.

Blood Science (Baltimore, Md.)

|April 11, 2022

Summary

This summary is machine-generated.

Aging hematopoietic stem cells (HSCs) lose their blood-forming capacity and favor myeloid cell production. This review explores how inflammation contributes to HSC aging and suggests future research directions.

Keywords:

Hematopoietic stem cells aging Inflammation

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Last Updated: Sep 27, 2025

Author Spotlight: Advancing Hematopoietic Research Using Stromal Cell Isolation for Single Cell Sequencing

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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

Area of Science:

Hematology
Immunology
Gerontology

Background:

Hematopoietic stem cells (HSCs) are crucial for lifelong blood cell production.
Aging impairs HSC function, leading to reduced repopulation capacity and skewed myeloid differentiation.
Intrinsic and extrinsic factors contribute to HSC aging.

Purpose of the Study:

To review the role of aging-associated inflammation in HSC aging.
To discuss potential research avenues for understanding inflammation's impact on HSCs.

Main Methods:

Literature review focusing on aging, inflammation, and HSC biology.
Synthesis of current knowledge on the mechanisms linking inflammation to HSC aging.

Main Results:

Aging is associated with chronic, low-grade inflammation (inflammaging).
Inflammatory mediators can directly and indirectly affect HSC function and aging.
Aged HSCs exhibit altered responses to inflammatory signals.

Conclusions:

Aging-associated inflammation is a significant driver of HSC aging.
Targeting inflammation may offer therapeutic strategies to rejuvenate HSCs.
Further research is needed to elucidate specific inflammatory pathways impacting HSC aging.