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Capecitabine-Induced Enterocolitis.

Muzammil Khan1, Robert Kleyner2, Sadia Abbasi1

  • 1Internal Medicine, Stony Brook University Hospital, Stony Brook, USA.

Cureus
|April 11, 2022
PubMed
Summary
This summary is machine-generated.

Capecitabine chemotherapy can cause rare but severe enterocolitis, leading to ileus. This case highlights successful conservative management of this serious gastrointestinal side effect in a breast cancer patient.

Keywords:
capecitabinechemotherapy-related toxicitydiarrheaenterocolitisileus

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Area of Science:

  • Oncology
  • Gastroenterology
  • Pharmacology

Background:

  • Capecitabine is an FDA-approved oral chemotherapy for metastatic colorectal and breast cancer.
  • Common side effects include GI upset, fatigue, and hematologic changes.
  • Enterocolitis is a rare but serious gastrointestinal complication of capecitabine therapy.

Observation:

  • A 53-year-old female patient with metastatic breast cancer developed severe enterocolitis.
  • The enterocolitis progressed to ileus during capecitabine chemotherapy.
  • The patient's condition was managed conservatively.

Findings:

  • This case illustrates a rare presentation of capecitabine-induced enterocolitis.
  • Successful conservative management of capecitabine-induced enterocolitis and ileus is demonstrated.
  • Early recognition and management are crucial for this adverse event.

Implications:

  • Highlights the importance of monitoring for rare but severe GI side effects of capecitabine.
  • Suggests conservative management can be effective for capecitabine-induced enterocolitis with ileus.
  • Informs clinical practice regarding capecitabine toxicity in cancer patients.