Related Experiment Video
Updated: Sep 27, 2025

Chemical Dimerization-Induced Protein Condensates on Telomeres
Published on: April 12, 2021
PML nuclear body biogenesis and oligomerization-driven leukemogenesis
Yuwen Li1, Xiaodan Ma1, Guoyu Meng1
1State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Abstract:
PML nuclear bodies (NBs), which are increasingly recognized as the central hub of many cellular signaling events, are superassembled spherical complexes with diameters of 0.1-2 μm. Recent studies reveal that RING tetramerization and B1-box polymerization are key factors to the overall PML NBs assembly. The productive RBCC oligomerization allows subsequent PML biogenesis steps, including the PML auto-sumoylation and partners recruitment via SUMO-SIM interactions. In promyelocytic leukemia, the oncoprotein PML/RARα (P/R) inhibits PML NBs assembly and leads to a full-fledged leukemogenesis. In this review, we review the recent progress in PML and acute promyelocytic leukemia fields, highlighting the protein oligomerization as an important direction of future targeted therapy.
More Related Videos
Related Concept Videos
Abnormal Proliferation
The Nucleolus
Regulation of Nuclear Protein Sorting
Intralumenal Vesicles and Multivesicular Bodies
Nuclear Protein Sorting
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
Chromatin Structure Regulates pre-mRNA Processing
The chromatin structure, especially...

