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Updated: Sep 27, 2025

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
Epidemic changepoint detection in the presence of nuisance changes
Julius Juodakis1, Stephen Marsland1
1School of Mathematics and Statistics, Victoria University of Wellington, PO Box 600, Wellington, 6140 New Zealand.
Abstract:
Many time series problems feature epidemic changes-segments where a parameter deviates from a background baseline. Detection of such changepoints can be improved by accounting for the epidemic structure, but this is currently difficult if the background level is unknown. Furthermore, in practical data the background often undergoes nuisance changes, which interfere with standard estimation techniques and appear as false alarms. To solve these issues, we develop a new, efficient approach to simultaneously detect epidemic changes and estimate unknown, but fixed, background level, based on a penalised cost. Using it, we build a two-level detector that models and separates nuisance and signal changes. The analytic and computational properties of the proposed methods are established, including consistency and convergence. We demonstrate via simulations that our two-level detector provides accurate estimation of changepoints under a nuisance process, while other state-of-the-art detectors fail. In real-world genomic and demographic datasets, the proposed method identified and localised target events while separating out seasonal variations and experimental artefacts.
Supplementary Information:
The online version contains supplementary material available at 10.1007/s00362-022-01307-x.
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