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[Urinary trehalase activity during normal pregnancy: tubular dysfunctions]
Nihon Sanka Fujinka Gakkai Zasshi
|November 1, 1986
Summary
Normal pregnancy is associated with kidney tubular dysfunction, indicated by increased urinary trehalase, beta 2-microglobulin, and N-acetyl-beta-D-glucosaminidase levels. These markers normalize postpartum, suggesting temporary renal changes during gestation.
Area of Science:
- Nephrology
- Biochemistry
- Reproductive Medicine
Context:
- Pregnancy involves significant physiological adaptations, including potential alterations in renal function.
- Assessing kidney health during pregnancy is crucial for maternal and fetal well-being.
Purpose:
- To investigate the presence and extent of renal tubular dysfunction during and after normal pregnancy.
- To evaluate changes in specific urinary biomarkers indicative of tubular damage.
Summary:
- Urinary trehalase, beta 2-microglobulin (β2-MG), and N-acetyl-beta-D-glucosaminidase (NAG) were measured in pregnant women and controls.
- Elevated urinary trehalase and NAG were observed throughout pregnancy, with β2-MG increasing in the third trimester.
- Postpartum, these marker levels returned to baseline, indicating transient tubular dysfunction.
Impact:
- This study provides evidence of subclinical tubular dysfunction occurring during normal pregnancy.
- Findings highlight the importance of monitoring renal function markers in pregnant individuals.
- Suggests that physiological changes in pregnancy can impact kidney brush border integrity.