Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.5K
T Cell Types and Functions01:24

T Cell Types and Functions

1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

9.4K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.4K
MicroRNAs01:22

MicroRNAs

22.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
22.0K
Epigenetic Regulation01:46

Epigenetic Regulation

31.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.4K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

62
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
62

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence of sarcopenia in patients with rheumatoid arthritis: a cross-sectional study.

RMD open·2026
Same author

Metabolic Reprogramming-Driven Lactylation: Emerging Mechanisms Linking DNA Damage Repair and Chemoresistance in Cancer.

Cells·2026
Same author

Comparative analysis of whole spine and sacroiliac joint magnetic resonance SPARCC scores in patients with SAPHO syndrome and ankylosing spondylitis.

Frontiers in immunology·2026
Same author

Interpretable machine learning to predict NOAF in ICU patients with CKD: validation in US and Chinese cohorts.

Frontiers in medicine·2026
Same author

Correction: Study on the mechanism of 18β-glycyrrhetinic acid inhibiting the proliferation of renal cancer cells by inducing autophagy through the miR-27a-5p/LC3 axis.

Frontiers in oncology·2026
Same author

Kinetic modeling of anthocyanin extraction-degradation from dragon fruit peel via NADES-ATPS.

Food chemistry·2026

Related Experiment Video

Updated: Sep 27, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

410

MicroRNA-Mediated Epigenetic Regulation of Rheumatoid Arthritis Susceptibility and Pathogenesis.

Cen Chang1,2, Lingxia Xu1,2, Runrun Zhang3

  • 1Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Frontiers in Immunology
|April 11, 2022
PubMed
Summary

MicroRNAs (miRNAs) are key regulators in rheumatoid arthritis (RA) development. This review maps miRNA roles in RA pathogenesis, diagnosis, and therapy, highlighting their potential as biomarkers and therapeutic targets.

Keywords:
epigeneticsmicroRNApathogenesisrheumatoid arthritissusceptibility

More Related Videos

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

367
Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

8.6K

Related Experiment Videos

Last Updated: Sep 27, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

410
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

367
Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
09:18

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

8.6K

Area of Science:

  • Immunology
  • Genetics
  • Molecular Biology

Background:

  • Rheumatoid arthritis (RA) pathogenesis involves complex molecular dysregulation.
  • MicroRNAs (miRNAs) are critical post-transcriptional regulators implicated in various diseases, including RA.
  • A comprehensive understanding of miRNA regulatory networks in RA is currently lacking.

Purpose of the Study:

  • To review the multifaceted roles of miRNAs in rheumatoid arthritis (RA) susceptibility, pathogenesis, diagnosis, and therapeutic strategies.
  • To elucidate how miRNAs interact with key cellular components and pathways in RA.
  • To highlight the potential of miRNAs as diagnostic biomarkers and therapeutic targets for RA.

Main Methods:

  • Literature review synthesizing current research on miRNAs in RA.
  • Analysis of miRNA expression patterns and their target genes/pathways in RA.
  • Evaluation of genetic variants in miRNAs and their association with RA susceptibility.
  • Assessment of circulating miRNAs as diagnostic and prognostic biomarkers.
  • Review of miRNA-based therapeutic interventions for RA.

Main Results:

  • Numerous miRNAs are aberrantly expressed in RA, targeting key pathways like NF-κB, Fas-FasL, JAK-STAT, and mTOR.
  • Genetic variants in miR-499 and miR-146a contribute to RA susceptibility.
  • miRNAs regulate T cell differentiation (Th17, Treg), offering gene therapy potential for immune modulation in RA.
  • Circulating miRNAs show promise as diagnostic/prognostic biomarkers, especially when combined with anti-cyclic citrullinated peptide (ACCP) antibodies for seronegative RA.
  • miRNAs are emerging biomarkers for treatment response and resistance to disease-modifying anti-rheumatic drugs (DMARDs) and immunotherapy.

Conclusions:

  • miRNAs are pivotal in RA pathogenesis and represent promising targets for diagnosis and therapy.
  • miRNA-based interventions offer a novel approach for RA treatment, including autotherapeutic strategies.
  • Further research into miRNA regulatory networks will enhance understanding and treatment of RA.