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Related Experiment Video

Updated: Sep 27, 2025

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Stereotactic radiotherapy for brain oligometastases.

Marco Lupattelli1, Paolo Tini2, Valerio Nardone3

  • 1Radiation Oncology Section, University of Perugia and Perugia General Hospital, Italy.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
|April 11, 2022
PubMed
Summary

Stereotactic radiotherapy (SRT) effectively treats brain metastases, with single or multiple fractions offering good local control and safety. Treatment choice depends on lesion size, location, and patient status, balancing efficacy with reduced neurotoxicity.

Keywords:
brain metastaseshypofractionationlocal controloligometastasisradionecrosisradiosurgerystereotactic radiotherapytoxicity

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Area of Science:

  • Oncology
  • Neurology
  • Radiotherapy

Background:

  • Brain metastases are common in cancer patients, often originating from breast, lung, or melanoma.
  • Magnetic resonance imaging (MRI) and computed tomography (CT) are crucial for diagnosis and treatment planning.
  • Stereotactic radiotherapy (SRT) is a primary treatment modality for brain metastases.

Purpose of the Study:

  • To review the application and outcomes of single-fraction and fractionated stereotactic radiotherapy for brain metastases.
  • To compare the efficacy and safety profiles of different SRT fractionation schedules.
  • To highlight the factors influencing treatment decisions and outcomes in brain metastases radiotherapy.

Main Methods:

  • Review of diagnostic imaging techniques including MRI and CT for treatment planning.
  • Description of single-fraction SRT for limited lesions and fractionated SRT for larger or complex cases.
  • Analysis of dose-dependency on tumor size for local control in single-fraction SRT.

Main Results:

  • Both single-fraction and fractionated SRT achieve satisfactory local control rates.
  • SRT demonstrates good tolerance with a low risk of transient acute adverse events.
  • Radiation necrosis incidence correlates with the irradiated brain volume, suggesting fractionation may reduce this risk.

Conclusions:

  • Single and fractionated SRT are effective treatments for brain metastases, offering comparable outcomes.
  • Fractionated SRT may be preferred for larger lesions, eloquent areas, or to mitigate neurotoxicity.
  • Further randomized trials are needed to directly compare safety and efficacy of different SRT fractionation schedules.