Prostaglandins in disorders of the intestinal tract: a review

Prostaglandins (PGs) are natural oxygenated products of polyunsaturated fatty acids. They have multiple effects on the gastrointestinal tract. Their major physiological roles in the intestine are the promotion of solute and water secretion and the control of bowel motility. Prostaglandins have a role in the pathogenesis of diarrhea in a wide spectrum of gastrointestinal disorders. The effects and the potential contribution of PGs in various gastrointestinal disorders are discussed, and therapeutic modalities in these disorders are reviewed.