Association between ambient particulate matter (PM_2.5/PM₁₀) and first incident ST-elevation myocardial infarction in...

Interests in evaluation of the effect of air pollution and weather conditions on cardiovascular disease have increased. However, the relationship between short-term particulate matter (PM) exposure and first incident ST-elevation myocardial infarction (STEMI) remains unclear. Medical records were collected from December 2013 to December 2016. A total of 1354 patients with first incident STEMI were included. The daily average of air pollution and weather conditions were calculated. In this case-crossover study, conditional logistic regression was performed to assess the association between daily concentrations of PM and first incident STEMI. The daily average of PM_2.5 and PM₁₀ were 58.9 μg/m³ and 80.2 μg/m³, respectively. In this case-crossover study, single-pollutant models showed that each 10 μg/m³ increase in PM_2.5 was associated with a percent change of 3.36, 95% confidence interval (CI): (1.01-5.77), or in PM₁₀ percent change of 2.1%, 95%CI: (0.2-4.04) for patients with first incident STEMI. The association remained stable after adjusting for ozone (O₃). The results from subgroup analysis showed the association slightly enhanced in women, elder patients, patients with history of diabetes, patients without history of smoking, and cold seasons. The p values were not significant between these strata, which may be due to small sample size. This investigation showed that short-term PM exposure associated with first incident STEMI in Suzhou. Given the effect of PM on the first incident STEMI, strategies to decrease PM should be considered.