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Altered Cardiac Repolarization in Chronic Obstructive Pulmonary Disease.
Fatih Alper Uğuz1, Fulsen Bozkuş1, Ekrem Aksu2
1Department of Chest Diseases,Kahramanmaraş Sütçü İmam University, Faculty of Medicine, Kahramanmaraş, Turkey.
Turkish Thoracic Journal
|April 11, 2022
Summary
Patients with severe chronic obstructive pulmonary disease (COPD) show prolonged QTc and QTd intervals, indicating increased risk for cardiac events. These repolarization changes may be linked to hypoxemia and airway obstruction in COPD patients.
Area of Science:
- Cardiology
- Pulmonology
- Medical Diagnostics
Background:
- Altered cardiac repolarization is a known risk factor for malignant arrhythmias and sudden cardiac death.
- Patients with chronic obstructive pulmonary disease (COPD) have an elevated risk of cardiac arrhythmias and sudden death.
- Electrocardiogram (ECG) repolarization measurements may identify individuals with COPD at risk for lethal arrhythmias.
Purpose of the Study:
- To investigate the relationship between ECG repolarization parameters and demographic, clinical, and biochemical factors in COPD patients.
- To evaluate QTc interval and QT dispersion as potential markers for sudden cardiac death risk in COPD.
- To compare repolarization parameters between different severity groups of COPD.
Main Methods:
- A study involving 35 patients with Global Initiative for Chronic Obstructive Lung Disease (GOLD) A-B and 35 with GOLD C-D.
- Measurement of cardiac repolarization and dispersion using 12-lead electrocardiogram (QTc interval, QT dispersion, TP-e, Tp-e/QTc).
- Definition of prolonged QTc interval as >440 ms in men and >460 ms in women.
Main Results:
- Significantly prolonged QTc and QTd values were observed in the GOLD C-D group compared to the GOLD A-B group (P < .001).
- QTc values showed a negative correlation with forced expiratory volume in 1 second/forced vital capacity ratio and partial pressure of oxygen (P = .030, r = -0.260; P = .006, r = -0.332).
- No significant differences in TP-e and Tp-e/QTc were found between the groups.
Conclusions:
- QTc and QTd are non-invasive markers of arrhythmogenicity, and their prolongation is associated with COPD.
- Altered cardiac repolarization and prolonged repolarization dispersion in COPD patients may be linked to hypoxemia and airway obstruction.
- These cardiac repolarization alterations may increase the risk of malignant ventricular arrhythmias and sudden cardiac death in COPD patients.
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