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Updated: Sep 27, 2025

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
COVID-19 Vaccination and Uveitis: Epidemiology, Clinical Features and Visual Prognosis
Nawfel Ferrand1, Massimo Accorinti2, Mamta Agarwal3
1Department of Ophthalmology, University Eye Hospital, Tuebingen, Germany.
Purpose:
To study the epidemiological and clinical features of uveitis post-COVID-19 vaccination.
Patients And Methods:
Retrospective chart review of patients presenting with uveitis after COVID-19 vaccination in tertiary uveitis services.
Results:
In total, 25 patients, 76% females, mean age 43.2 years, were included. Uveitis occurred after Pfizer, Moderna, Astra-Zeneca and Covaxin vaccination. Anterior uveitis was the most frequent type of uveitis (56%). History of uveitis was found in 19 cases (76%), among whom 90.9% of the tested patients developed anti-Sars-CoV-2 spike antibodies after vaccination. In a mean follow-up of 5 months, one-line decrease in visual acuity was found in 12% of patients. During post-vaccine uveitis, 15.8% of cases needed an increase in their systemic therapy. According to Naranjo score, new-onset uveitis had a higher probability of being associated with vaccination (p < .01).
Conclusion:
COVID-19 vaccination can cause uveitis but has no significant impact on the visual prognosis after resolution.
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