Radiomics/Radiogenomics in Lung Cancer: Basic Principles and Initial Clinical Results

Area of Science:

• Oncology
• Medical Imaging
• Genomics

Background:

• Lung cancer remains a leading cause of cancer mortality globally.
• Traditional research relies on genomic and high-throughput methods to understand lung cancer pathobiology.
• Radiomics, quantitative analysis of medical images, offers novel insights into cancer research.

Purpose of the Study:

• To provide a concise overview of radiogenomics in lung cancer research.
• To discuss the fundamental aspects and limitations of radiogenomics.
• To highlight the clinical applications for lung cancer researchers, clinicians, and patients.

Main Methods:

• Review of existing literature on radiogenomics, genomics, and radiomics in lung cancer.
• Integration of genomic, transcriptomic, and proteomic data with radiological features.
• Analysis of the associations between molecular and imaging phenotypes.

Main Results:

• Radiogenomics enables understanding the biological basis of imaging phenotypes in lung cancer.
• Associations between molecular features and radiological characteristics are established.
• The potential of radiogenomics to advance lung cancer research and clinical practice is highlighted.

Conclusions:

• Radiogenomics represents a promising interdisciplinary field for lung cancer research.
• Understanding radiogenomic principles is crucial for its effective clinical application.
• Addressing current limitations is key to fully realizing the potential of radiogenomics in lung cancer care.